Non-Invasive Intracranial Pressure (ICP) Meter Head Frame Modification for ChildrenPI: Remis Bistras, PhD, MBA
AFFILIATION Vittamed Corporation
Medical need exist for accurate non-invasive Intracranial Pressure measurement for multiple groups of pediatric patients, such as hydrocephalus, kids with traumatic brain injuries, Pseudotumor cerebri and others. They all could benefit from ICP measurements and management but currently only invasive methods are available, which require placing intraventricular catheter for Hydrocephalus or TBI patients or lumbar puncture for neurological patients.
Vittamed has developed non-invasive ICP meter which is using safe ultrasound technology and measures ICP by using blood flow parameters in two pieces of ophthalmic artery: intracranial and extracranial.
The non-invasive ICP meter has been validated in clinical studies for adult population (18 years and older) conducted at several European sites (Publication in Neurology, 2013 and others). Clinical studies have found that there is a high correlation between ICP measurements taken by our device and the current gold standard invasive techniques (standard deviation only 2.3 mmHg with a very high precision vs lumbar puncture or intraventricular catheter). This is clinically a totally acceptable standard deviation; typically invasive devices compare to one another with a SD >2-3 mmHg;
Clinical studies also found that ICP meter has a very good to excellent diagnostic value for patients with elevated ICP (> 15 mmHg); clinically tested: Specificity – up to 96%; Sensitivity – up to 84%; overall accuracy – up to 96%; (See publication in Neurology, 2013, Neurological Research 2014, and others). We would like to adopt this technology for pediatric patients (older than 8 years). For this we will need to redesign head frame used for ultrasonic measurement to fit comfortable children’s head; we also will design the head frame so that ultrasound transducers could insonate simultaneously two segments of ophthalmic artery (intracranial and extracranial) for children. The prototype will be produced and tested for comfort and functionality.
Development of Laser Speckle Contrast Imaging as a Non-Invasive Diagnostic for Retinopathy of PrematurityPIs: Janet Alexander, MD and Jason Brooke, MSE, JD
AFFILIATIONS University of Maryland Baltimore and Vasoptic Medical, Inc.
Imaging Through the Eardrum for Improved Diagnosis of Middle Ear DiseasePI: Ryan Shelton, PhD
AFFILIATION: PhotoniCare, Inc
Magnetic System to Direct Therapy to Middle Ear Infections in ChildrenPIs: Benjamin Shapiro, PhD and Diego Preciado, MD, PhD
AFFILIATION Otomagnetics LLC and Children’s National Health System
Middle ear infections are the leading cause for pediatrician visits. In the US, there are an estimated 15 million cases/year of acute otitis media (AOM) in children ≤ 5 years old. Approximately 20% of these cases progress on to chronic otitis media with effusion (COME). COME is associated with hearing loss, delayed speech development, and increased incidence of permanent middle ear damage. Tube insertion through the ear drum (tympanostomy tube placement) for COME and recurrent AOM is the most common pediatric surgical procedure in the US, and requires general anesthesia with its attendant risks. There is no effective non-surgical treatment for COME or recurrent AOM.
At the University of Maryland, we have invented a system to magnetically deliver therapy to ear compartments. Our approach has the potential to improve both the treatment of AOM (by delivering drugs to just the middle ear instead of systemic administration) and COME (by eliminating/reducing the need for tubes).
Otomagnetics was formed in March 2012 to commercialize the technology. The company has already won non-dilutive grants from the State of Maryland (MIPS, TEDCO, BioMaryland), as well as a seed grant from Children’s/UMD. NCC-PDI funding is sought to move the technology from the laboratory towards FDA allowance and to clinical use.
Engineering Optimization of a Low-Cost Multifunctional IncubatorPI: Govind Rao, PhD
AFFILIATION University of Maryland Baltimore; Center for Advanced Sensor Technology